The Mayor believes the scheme will add to the Capital's entrepreneur scene and will benefit the growing Tech City area of East London.
"With so many promising start-ups emerging from the Old Street area, it is the perfect focal point for ambitious young entrepreneurs across the country.
"I look forward to hearing more about the businesses and ideas that will be coming out of the Entrepreneur First scheme in the months and years to com
Those who are accepted onto the program will be offered a two-years of training and mentoring alongside access to a network of the UK's leading entrepreneurs, investors and major employers.
CEO of Entrepreneur First, Matt Clifford, is pleased with the wide range of people from different backgrounds who've applied, but is welcoming more and wants it known that people from any university can apply before the 31 December deadline.
"History shows us that the best ideas and businesses don't just come from the traditional 'red brick' universities, says Clifford. "It's great to see that students from across the country believe that entrepreneurialism is the right career path for them."
For more information on how to apply, click here