"The recovery we need has got to be a private sector-led recovery, a recovery with 'Made in Britain' stamped all over it," said the PM at Microsoft headquarters in central London earlier today.
Cameron made a direct plea to the audience, calling for "everyone who's sitting at home or at their desk thinking about starting their own business" to respond to the government's appeal. "Now is the time to do it," he said.
But the Conservative leader made the clear point that there would be no hand-holding or hand-outs for would-be entrepreneurs. The enterprise community will have to pull together independently remove the barriers to entry for new entrepreneurs.
"Those who argue we just need to pump more money in just don't get it," he said. "We don't have any, and even if we did it would mean business hit by higher interest rates, higher taxes down the line, and that is the opposite of what we need.
"We need to set business free to drive our economy forward, not burden business with more taxes or hold our economy back."
Cameron said that the new Start Up Britain initiative, supported by Smarta, was "unbelievably important" for the UK economy.
"If you've been turning over a good idea for years, now is the time to make something of it," he said. "If you're working for a big firm but know you could do a better job on your own, now is the time to make the leap. If you're dreaming about starting up the next great British brand, now is the time to make it happen."
He concluded with this rabble-rouser: "Seize this moment, take these opportunities, make it happen - and together we can drive our economy forward."
Visit the StartUp Britain website.